Low Dose HRT and Cholesterol
It has long been known that hormone replacement therapy--HRT--can raise the
good cholesterol and lower the bad cholesterol levels in menopausal women; this
is one of the many reasons that HRT is believed to reduce the risk of heart
disease in women. What was not known is whether this is a dose related effect.
Now, researchers from Columbia University have shown in a large-scale clinical
trial that low-dose HRT is also effective at managing cholesterol levels. This
data comes from the Women's HOPE Study [Fertility and Sterility,
The HOPE Study findings revealed that low-dose HRT was able to raise the good
cholesterol, or HDL by 10% and lower bad cholesterol, or LDL by 7%. These results
are similar to those shown with the most commonly prescribed doses of HRT.
This is very good news for women who seek the benefits of HRT, but who want
to reduce their dose in order to reduce their risk of side effects.
The Women's HOPE Study is the longest controlled, randomized clinical trial
ever done to asses the efficacy and benefits of low-dose HRT. This study has
also established that low-dose HRT is as effective as standard doses in treating
menopausal symptoms--such as hot flashes, night sweats and sleep disturbances--with
fewer side effects.
For more information, click here.
Created: 9/13/2001  - Donnica Moore, M.D.