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Women's HOPE Study
Health, Osteoporosis, Progestin, Estrogen Study

Good news for women who have had undesirable side effects such as breakthrough or unpredictable bleeding from their HRT (hormone replacement therapy)! A recent study in the journal Fertility and Sterility (June 2001) reports that lower doses of HRT than are most commonly prescribed actually have higher rates of amenorrhoea (no bleeding). 

This study is called the Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) study.  It was conducted at more than 50 centers across the United States and included 2,673 healthy postmenopausal women.  The doses used were:

  • Premarin, or conugated equine estrogen (CEE) 0.625 mg
  • Prempro, or CEE 0.625 mg with medroxyprogesterone acetate (MPA) 2.5 mg
  • CEE 0.45 mg with MPA 2.5 mg
  • CEE 0.45 mg with MPA 1.5 mg
  • CEE 0.3 mg with MPA 1.5 mg
  • Placebo

The authors concluded that once a low dose combination product becomes available, this may be a worthwhile dosage starting point for newly menopausal women.

Another article in the same issue of this journal (Fertility and Sterility, June 2001) indicated that lower-dosage combinations of CEE and MPA are as effective as doses commonly prescribed for relieving the symptoms of menopause (hot flashes, night sweats, etc.) and vaginal atrophy (which produces vaginal dryness).

For more information on hormone replacement therapy, click here.

Created: 6/26/2001  -  Donnica Moore, M.D.

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